[HTML][HTML] Genome-wide association studies

E Uffelmann, QQ Huang, NS Munung… - Nature Reviews …, 2021 - nature.com
… GWAS often require very large sample sizes to identify reproducible genome-wide significant
associations and the desired sample size can be determined using power calculations in …

Benefits and limitations of genome-wide association studies

V Tam, N Patel, M Turcotte, Y Bossé, G Paré… - Nature Reviews …, 2019 - nature.com
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Genome-wide association studies: theoretical and practical concerns

WYS Wang, BJ Barratt, DG Clayton… - Nature Reviews Genetics, 2005 - nature.com
… the genome-wide associationstudies that are designed and executed with low statistical
power and inadequate quality control. Here, in the context of genome-wide association studies

Genome-wide association studies for common diseases and complex traits

JN Hirschhorn, MJ Daly - Nature reviews genetics, 2005 - nature.com
… , which include both LINKAGE MAPPING and genome-wide association studies. The main
… present arguments as to why genome-wide association studies might be advantageous for …

[HTML][HTML] Chapter 11: Genome-wide association studies

WS Bush, JH Moore - PLoS computational biology, 2012 - journals.plos.org
… We will focus here on the genome-wide association study or GWAS that measures and
analyzes DNA sequence variations from across the human genome in an effort to identify genetic …

The road to genome-wide association studies

L Kruglyak - Nature Reviews Genetics, 2008 - nature.com
The recent crop of results from genome-wide association studies might seem like a sudden
development. However, this blooming follows a long germination period during which the …

Biostatistical aspects of genomewide association studies

A Ziegler, IR König… - … Journal: Journal of …, 2008 - Wiley Online Library
… human genome for association is a novel and promising approach to unravelling the
genetic basis of complex genetic diseases. In these genome-wide association studies (GWAs), …

Bioinformatics challenges for genome-wide association studies

JH Moore, FW Asselbergs, SM Williams - Bioinformatics, 2010 - academic.oup.com
… that can be used to carry out genome-wide association studies (GWASs). The availability of
… the discovery of new associations that have been replicated in multiple studies. However, it …

Robust relationship inference in genome-wide association studies

A Manichaikul, JC Mychaleckyj, SS Rich, K Daly… - …, 2010 - academic.oup.com
… We present a novel framework for relationship inference, Kinship-based INference for
Genome-wide association studies (KING), together with a rapid algorithm for relationship inference …

Analysing biological pathways in genome-wide association studies

K Wang, M Li, H Hakonarson - Nature Reviews Genetics, 2010 - nature.com
genome-wide association (GWA) studies. An example is shown to illustrate that many
genes in a susceptibility pathway may show evidence of association, although not genome-wide